Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates

dc.creatorMolino, JayES
dc.creatorJojlova, SvetlanaES
dc.creatorHirofumi Daiguji andES
dc.creatorTakemura, FumioES
dc.date.accessioned2021-05-18T19:55:39Z
dc.date.available2021-05-18T19:55:39Z
dc.date.issued2019-01-16
dc.description.abstractHollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbed to the bubble surface by physisorption. Then, the coated microbubbles were spontaneously released from the droplet´s interior into the continuous phase. To increase the production yield of hollow microcapsules in this method, ultrasound was applied to enhance bubble nucleation inside the droplets. Thus to attain uniform hollow PLA microcapsules, the optimum PLA concentration with ultrasound was 30 g L −1 , which is higher than that without ultrasound (2 g L−1 ). At the optimum concentration, the average radius was 0.54 µm, with a polydispersity index of 21.2%. It was found that the equilibrium size of the microbubble template radius was the same with and without ultrasound. The production yield had a tenfold increase when ultrasound was employed.en_US
dc.formatapplication/pdfES
dc.format.extent213-224 páginasES
dc.identifier.otherDOI: 10.3844/ajassp.2019.213.224
dc.identifier.urihttp://repositorio2.udelas.ac.pa/handle/123456789/362
dc.languageengES
dc.publisher.American Journal of Applied Sciencesen_US
dc.relation.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/ES
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/ES
dc.rightsinfo:eu-repo/semantics/openAccessES
dc.rights.licensehttps://creativecommons.org/licenses/by-sa/2.0/uk/ES
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/ES
dc.subjectBiodegradable Microcapsulesen_US
dc.subjectDrug Deliveryen_US
dc.subjectMass Production of Hollow Capsulesen_US
dc.subjectMicroencapsulationen_US
dc.subjectUltrasound Enhanced Fabricationen_US
dc.subjectUltrasound Contrast Agentsen_US
dc.titleMass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templatesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:eu-repo/semantics/updatedVersionES

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