Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates
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Date
2019-01-16
Authors
Molino, JayJojlova, SvetlanaHirofumi Daiguji andTakemura, Fumio
Asesor
Journal Title
Journal ISSN
Volume Title
Publisher
.American Journal of Applied Sciences
Abstract
Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated
using the bubble template method. In this method, microbubbles nucleated
inside droplets of a dichloromethane solution of PLA which were located in
a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles
formed when PLA adsorbed to the bubble surface by physisorption. Then,
the coated microbubbles were spontaneously released from the droplet´s
interior into the continuous phase. To increase the production yield of
hollow microcapsules in this method, ultrasound was applied to enhance
bubble nucleation inside the droplets. Thus to attain uniform hollow PLA
microcapsules, the optimum PLA concentration with ultrasound was 30 g
L
−1
, which is higher than that without ultrasound (2 g L−1
). At the optimum
concentration, the average radius was 0.54 µm, with a polydispersity index
of 21.2%. It was found that the equilibrium size of the microbubble
template radius was the same with and without ultrasound. The production
yield had a tenfold increase when ultrasound was employed.
Description
Keywords
Biodegradable MicrocapsulesDrug DeliveryMass Production of Hollow CapsulesMicroencapsulationUltrasound Enhanced FabricationUltrasound Contrast Agents
Cómo citar
Jay, M. et al. (2019). Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates. .American Journal of Applied Sciences. http://repositorio2.udelas.ac.pa/handle/123456789/362